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CRM1 degrader 1

CRM1 degrader 1 (1l) is a low toxic chromosome region maintenance 1 (CRM1) degrader. CRM1 is the sole nuclear exporter of several tumor suppressor, a growth regulatory protein as an attractive cancer agent target. CRM1 degrader 1 induces the apoptosis in gastric carcinoma and selectively inhibits proliferation of gastric cancer[1].

Product Specifications

CAS Number

2986647-41-8

UNSPSC

12352005

Target

CRM1

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/crm1-degrader-1.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(OC[C@H]2CC=CC(O2)=O)=C(C=C1)C(C)C

Molecular Formula

C16H20O3

Molecular Weight

260.33

References & Citations

[1]Xu HW, et al. A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27. Eur J Med Chem. 2020;206:112708.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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