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H3R antagonist 2

H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor (H3R) antagonist with a Ki of 170 nM for hH3R . H3R antagonist 2 shows inhibitory effects with IC50 values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and human monoamine oxidase B (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB[1].

Product Specifications

CAS Number

2970985-05-6

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Histamine Receptor; Monoamine Oxidase

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/h3r-antagonist-2.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC(OCCCCCN3CCCCCC3)=CC=C2OC4=C1C=CC=C4

Molecular Formula

C24H29NO3

Molecular Weight

379.49

References & Citations

[1]Łażewska D, et al. Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer's disease. Eur J Med Chem. 2020 Dec 1;207:112743.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

H3 Receptor; MAO-B

Frequently Asked Questions

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