S1427

S1427 is a tranylcypromine-derived LSD1 inhibitor with the IC50 of 390 nM and Ki of 80 nM. S1427 exhibits desirable hERG channel inhibition and microsomal stability profiles. Inhibition of LSD1 partially reduces the proliferation of cancer cells[1].

Product Specifications

CAS Number

[2447061-40-5]

UNSPSC

12352005

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s1427.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCC2(CC1)CCNC2)CN[C@H]3C[C@@H]3C4=C(C(F)=CC(F)=C4)OCC5=CC=CN=C5F

Molecular Formula

C25H29F3N4O2

Molecular Weight

474.52

References & Citations

[1]Yasuko Koda, et al. Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. ACS Med Chem Lett. 2022 Apr 29;13 (5) :848-854.