PROTAC VEGFR-2 degrader-2
PROTAC VEGFR-2 degrader-2 (PROTAC-4), a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC50> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC50> 100μM) [1].
Product Specifications
CAS Number
2353417-85-1
UNSPSC
12352005
Target
PROTACs; VEGFR
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-vegfr-2-degrader-2.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C(NC(NC2=CC=C(C=C2)C3=CC=CC4=C3C(N)=NN4C(CCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O)=O)=C1)F
Molecular Formula
C50H56FN9O6S
Molecular Weight
930.10
References & Citations
[1]Yuanyuan Shan, et al. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. Eur J Med Chem. 2020 Nov 1;205:112654.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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