PROTAC VEGFR-2 degrader-1
PROTAC VEGFR-2 degrader-1 (PROTAC-1), a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC50> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC50> 100 μM) [1].
Product Specifications
CAS Number
2601594-19-6
UNSPSC
12352005
Target
PROTACs; VEGFR
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-vegfr-2-degrader-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(C([C@@H](NC(CCCCCC(N2N=C(N)C3=C2C=CC=C3C4=CC=CC(NC(NC5=CC=CC(C(C)C)=C5)=O)=C4)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
Molecular Formula
C52H61N9O6S
Molecular Weight
940.16
References & Citations
[1]Yuanyuan Shan, et al. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. Eur J Med Chem. 2020 Nov 1;205:112654.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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