Antiproliferative agent-4
Product Specifications
UNSPSC Description
Antiproliferative agent-4 (compound 2y) has excellent anti-proliferative activity against certain cancer cell lines. Antiproliferative agent-4 reduces the mitochondrial membrane potential, and increases the apoptosis rate and the level of ROS on EC109. Antiproliferative agent-4 inhibits tumour growth in nude mice, with low toxicity[1].
Target Antigen
Apoptosis; Reactive Oxygen Species
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-4.html
Solubility
10 mM in DMSO
Smiles
CC1(C)CCC[C@]2(COC(O)=O)C1C[C@@H](O)[C@]3(C4=O)C2[C@@H](O)C[C@@H](C4=C)[C@H]3OC(C5=CC=C(CCl)C=C5)=O
Molecular Weight
547.04
References & Citations
[1]Huo JF, et al. Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents. Eur J Med Chem. 2020;208:112789.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146354/Antiproliferative-agent-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146354/
Clinical Information
No Development Reported
CAS Number
9007-83-4
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