HIV-1 inhibitor-29

HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC50 of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC50 = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC50 = 211 μM) . HIV-1 inhibitor-29 can be used for researching AIDS[1].

Product Specifications

CAS Number

[2642217-95-4]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-29.html

Solubility

10 mM in DMSO

Smiles

COC1=CC2=NC(NC3CCN(CC3)CC(N4CCOCC4)=O)=NC(OC5=C(C=C(C=C5C)C#N)C)=C2C=C1OC

Molecular Formula

C30H36N6O5

Molecular Weight

560.64

References & Citations

[1]Wang Z, Kang D, Feng D, et al. Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. Eur J Med Chem. 2020;206:112811.