HIV-1 inhibitor-29
HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC50 of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC50 = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC50 = 211 μM) . HIV-1 inhibitor-29 can be used for researching AIDS[1].
Product Specifications
CAS Number
[2642217-95-4]
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hiv-1-inhibitor-29.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=NC(NC3CCN(CC3)CC(N4CCOCC4)=O)=NC(OC5=C(C=C(C=C5C)C#N)C)=C2C=C1OC
Molecular Formula
C30H36N6O5
Molecular Weight
560.64
References & Citations
[1]Wang Z, Kang D, Feng D, et al. Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. Eur J Med Chem. 2020;206:112811.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Curated Selection
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