HIV-1 inhibitor-28
HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC50 of 58 nM for WT HIV-1 strain and an IC50 of 3.37 μM for HIV-1 WT reverse transcription (RT) . HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC50 = 38.6 μM) . HIV-1 inhibitor-28 can be used for researching AIDS[1].
Product Specifications
CAS Number
2642218-07-1
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hiv-1-inhibitor-28.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(C#N)=CC(C)=C1OC2=C3SCCC3=NC(NC4CCN(CC4)CC(N5CCOCC5)=O)=N2
Molecular Formula
C26H32N6O3S
Molecular Weight
508.64
References & Citations
[1]Wang Z, Kang D, Feng D, et al. Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. Eur J Med Chem. 2020;206:112811.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
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