TrxR-IN-4
TrxR-IN-4 (Compound 1b) is a potent inhibitor of TrxR. TrxR-IN-4 induces HepG2 cells apoptosis by activating the endoplasmic reticulum stress (ERS) . TrxR-IN-4 improves the CCl4-induced liver damage in vivo by down-regulation of TrxR expression and inflammation level[1].
Product Specifications
CAS Number
2414906-32-2
UNSPSC
12352100
Target
TrxR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trxr-in-4.html
Solubility
10 mM in DMSO
Smiles
FC(C=C1)=CC=C1[C@@H]2[N]3=CC(C=CC=C4)=C4[O-][Au+3]35[O-]C6=CC=CC=C6C=[N]5[C@H]2C7=CC=C(F)C=C7.F[P-](F)(F)(F)(F)F
Molecular Formula
C28H20AuF8N2O2P
Molecular Weight
796.40
References & Citations
[1]Bian M, et al. Synthesis and biological evaluation of gold (III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity. Eur J Med Chem. 2020 May 1;193:112234.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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