MAO-B-IN-10

MAO-B-IN-10 (compound 4f) is a potent, selective, BBB-penetrated MAO-B (monoamine oxidase-B) inhibitor, with IC50 of 5.3 μM. MAO-B-IN-10 can inhibit (58.2%) and disaggregate (43.3%) self-mediated Aβ (amyloid β) aggregation. MAO-B-IN-10 can be use for Alzheimer’s disease research[1].

Product Specifications

CAS Number

[2376710-36-8]

UNSPSC

12352005

Target

Amyloid-β; Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mao-b-in-10.html

Solubility

10 mM in DMSO

Smiles

CCN(C(OC1=C(C=C(C=C1)/C=C/C(N2CCC3=C(C2)C=CC=C3)=O)OC)=O)C

Molecular Formula

C23H26N2O4

Molecular Weight

394.46

References & Citations

[1]Sang Z, et al. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. Eur J Med Chem. 2020 May 15;194:112265.