FAAH/MAGL-IN-3
FAAH/MAGL-IN-3 (Compound 10) is an irreversible fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) dual inhibitor with IC50 values of 179 and 759 nM against FAAH and MAGL, respectively. FAAH/MAGL-IN-3 shows low PAMPA (Parallel Artificial Membrane Permeability Assay) permeability[1].
Product Specifications
CAS Number
2848719-34-4
UNSPSC
12352005
Target
FAAH; MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/faah-magl-in-3.html
Solubility
10 mM in DMSO
Smiles
CCCCC1=CC=C(C=C1)S(=O)(N2CCN(CC2)C(OC3=CC=C(C=C3)[N+]([O-])=O)=O)=O
Molecular Formula
C21H25N3O6S
Molecular Weight
447.50
References & Citations
[1]Alan Fulp, et al. Design and synthesis of endocannabinoid enzyme inhibitors for ocular indications. Bioorg Med Chem Lett. 2022 Jul 15;68:128763.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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