HIV-1 inhibitor-27

HIV-1 inhibitor-27 (compound 5) is a potent HIV-1 inhibitor with IC50s of 16 μM, 0.5 μM and 0.39 μM for HIV-1 YU2, NL4-3 and 89.6 strain, respectively. HIV-1 inhibitor-27 has low cytotoxicity with a CC50 of 128 μM in TZM-bl cells. HIV-1 inhibitor-27 can be used for researching AIDS[1].

Product Specifications

CAS Number

[2302046-54-2]

UNSPSC

12352211

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-27.html

Solubility

10 mM in DMSO

Smiles

[H][C@@]12CC(C)(CC[C@@]1(CC[C@@]3([C@@]2(C(C[C@@]4([C@]5(CC[C@@H](C(C)([C@@]5(CC[C@]43C)[H])C)O)C)[H])=O)[H])C)C(NCCCCCCCC(N[C@H]([C@H](CC(O)=O)O)CC(C)C)=O)=O)C

Molecular Formula

C46H78N2O7

Molecular Weight

771.12

References & Citations

[1]Takeuchi R, et al. Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds. Bioorg Med Chem Lett. 2022;69:128768.