Dyrk1A/B-IN-1
Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable DYRK1A and DYRK1B inhibitor with Kis of 67.8 nM and 237.9 nM, and IC50s of 1.1 μM and 0.8 μM, respectively. Dyrk1A/B-IN-1 is not toxic to human cells. Dyrk1A/B-IN-1 can be used for researching DYRK1A and DYRK1B cellular functions and their role in pathologies[1].
Product Specifications
CAS Number
3032401-50-3
UNSPSC
12352005
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dyrk1a-b-in-1.html
Solubility
10 mM in DMSO
Smiles
NC(C1=CC2=C(C=CC=C2S1)C3=CC=C(S3)C(NCC4=C(C=CC=C4)N)=O)=O
Molecular Formula
C21H17N3O2S2
Molecular Weight
407.51
References & Citations
[1]Segretti ND, et al. Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B. Bioorg Med Chem Lett. 2022;68:128764.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
Frequently Asked Questions
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