C-RAF kinase-IN-1
C-RAF kinase-IN-1 (compound 1l) is a potent inhibitor of C-RAF kinase with an IC50 of 0.193 μM. C-RAF kinase-IN-1 is a quinoline derivative. C-RAF kinase-IN-1 has the potential for the research of cancer diseases[1].
Product Specifications
CAS Number
2770957-08-7
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-raf-kinase-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=C(N=C(C(OC3=CC=C(C=C3)NC(NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=O)=C2)C)C=C1OCCN5CCOCC5
Molecular Formula
C32H30F6N4O5
Molecular Weight
664.59
References & Citations
[1]Zaraei SO, et al. Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity [published online ahead of print, 2022 May 5]. Eur J Med Chem. 2022;238:114434.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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