Mt KARI-IN-5

Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL) [1]

Product Specifications

CAS Number

[2413974-69-1]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mt-kari-in-5.html

Solubility

10 mM in DMSO

Smiles

CC(C1=CC=C(C=C1)S(=O)(NC2=NN=C(S2)C3=CC=C(S3)[N+]([O-])=O)=O)=O

Molecular Formula

C14H10N4O5S3

Molecular Weight

410.45

References & Citations

[1]Krishna VS, et al. Design and development of ((4-methoxyphenyl) carbamoyl) (5- (5-nitrothiophen-2-yl) -1,3,4-thiadiazol-2-yl) amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.