Mt KARI-IN-4
Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 72 μg/mL) [1].
Product Specifications
CAS Number
2413974-53-3
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mt-kari-in-4.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CC=C(O1)C2=NN=C(S2)NC(NC3=CC=C(C=C3)F)=S)[O-]
Molecular Formula
C13H8FN5O3S2
Molecular Weight
365.36
References & Citations
[1]Krishna VS, et al. Design and development of ((4-methoxyphenyl) carbamoyl) (5- (5-nitrothiophen-2-yl) -1,3,4-thiadiazol-2-yl) amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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