COX-2/5-LOX-IN-2

COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 5.40, 0.01 and 1.78 μM, respectively[1].

Product Specifications

CAS Number

[2410384-59-5]

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-5-lox-in-2.html

Solubility

10 mM in DMSO

Smiles

OC(C1=NN(C(C2=CC3=C(S2)C=CC=C3)=C1)C4=CC=C(C=C4)S(N)(=O)=O)=O

Molecular Formula

C18H13N3O4S2

Molecular Weight

399.44

References & Citations

[1]Gedawy EM, et al. Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors. Eur J Med Chem. 2020;189:112066.