BET-IN-7
BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis[1].
Product Specifications
CAS Number
303985-05-9
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bet-in-7.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(N=C(NC1=O)SCC2=CC=CC=C2Cl)C3=CC=CC=C3
Molecular Formula
C18H12ClN3OS
Molecular Weight
353.83
References & Citations
[1]Chen X, et al. Discovery of 2- ((2-methylbenzyl) thio) -6-oxo-4- (3,4,5-trimethoxyphenyl) -1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis. Eur J Med Chem. 2022 May 8;238:114423
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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