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BET-IN-7

BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis[1].

Product Specifications

CAS Number

303985-05-9

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bet-in-7.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(N=C(NC1=O)SCC2=CC=CC=C2Cl)C3=CC=CC=C3

Molecular Formula

C18H12ClN3OS

Molecular Weight

353.83

References & Citations

[1]Chen X, et al. Discovery of 2- ((2-methylbenzyl) thio) -6-oxo-4- (3,4,5-trimethoxyphenyl) -1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis. Eur J Med Chem. 2022 May 8;238:114423

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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