Zn (BQTC)

Zn (BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn (BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn (BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn (BQTC) has selectively antiproliferative activity against A549R cells. Zn (BQTC) can be used for researching anticancer[1].

Product Specifications

CAS Number

2785342-54-1

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zn-bqtc.html

Solubility

10 mM in DMSO

Smiles

O=C([N]12[Zn+2]([NH]3CC2)([NH]4CC3)[NH](CC4)CC1)CCCCCCOC5=C(OC6=CC=CC=C76)C7=NC8=CC=CC=C58.[Cl-].[Cl-]

Molecular Formula

C30H39Cl2N5O3Zn

Molecular Weight

653.95

References & Citations

[1]Wang ZF, et al. Novel bifluorescent Zn (II) -cryptolepine-cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells [published online ahead of print, 2022 Apr 30]. Eur J Med Chem. 2022;238:114418.