MGAT-IN-1
MGAT-IN-1 (compound 28) is a potent and non-selective GAT inhibitor. mGAT-IN-1 has a high inhibitory potency toward mGAT3, with an IC50 of 2.5 μM and pIC50 of 5.61[1].
Product Specifications
CAS Number
2556833-08-8
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mgat-in-1.html
Solubility
10 mM in DMSO
Smiles
CC(NCCC(N(CC/C=C(C1=C(C=CS1)C)/C2=C(C=CS2)C)C)C(NCC3=C(C=CC=C3)Cl)=O)=O
Molecular Formula
C28H34ClN3O2S2
Molecular Weight
544.17
References & Citations
[1]Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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