MGAT3/4-IN-1
MGAT3/4-IN-1 (compound 19b) is a potent mGAT3/mGAT4 inhibitor, with pIC50 values of 5.31 and 5.24, respectively. mGAT3/4-IN-1 exhibits a significant tactile allodynia reduction in diabetic neuropathic mice[1].
Product Specifications
CAS Number
2556833-57-7
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mgat3-4-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C(CCO)N(CC/C=C(C1=C(C)C=CS1)\C2=C(C)C=CS2)C)NCC3=C(Cl)C=CC=C3
Molecular Formula
C26H31ClN2O2S2
Molecular Weight
503.12
References & Citations
[1]Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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