MGAT3/4-IN-1

MGAT3/4-IN-1 (compound 19b) is a potent mGAT3/mGAT4 inhibitor, with pIC50 values of 5.31 and 5.24, respectively. mGAT3/4-IN-1 exhibits a significant tactile allodynia reduction in diabetic neuropathic mice[1].

Product Specifications

CAS Number

[2556833-57-7]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mgat3-4-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C(CCO)N(CC/C=C(C1=C(C)C=CS1)\C2=C(C)C=CS2)C)NCC3=C(Cl)C=CC=C3

Molecular Formula

C26H31ClN2O2S2

Molecular Weight

503.12

References & Citations

[1]Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.