LXRβ agonist-3
LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma[1].
Product Specifications
CAS Number
2416049-12-0
UNSPSC
12352005
Target
LXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lxrβ-agonist-3.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@]2(C3=CC=CC=C3N1)[C@@H](C4=CC(NC5=CC(S(C)(=O)=O)=C(C=C5)CO)=CC=C4)N(CC2)C(OC(C)(C)C)=O
Molecular Formula
C30H33N3O6S
Molecular Weight
563.66
References & Citations
[1]Chen H, Chen Z, Zhang Z, Li Y, Zhang S, Jiang F, Wei J, Ding P, Zhou H, Gu Q, Xu J. Discovery of new LXRβ agonists as glioblastoma inhibitors. Eur J Med Chem. 2020 May 15;194:112240.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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