PUL89 Endonuclease-IN-1

PUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 value of 0.88 μM and has antiviral activitiy[1].

Product Specifications

CAS Number

[391680-92-5]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

CMV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pul89-endonuclease-in-1.html

Solubility

10 mM in DMSO

Smiles

COC(C1=C(C(O)=NC(C2=CC=CS2)=N1)O)=O

Molecular Formula

C10H8N2O4S

Molecular Weight

252.25

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Tianyu He, et al. 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem. 2022 Apr 14;65 (7) :5830-5849.|[2]ianyu He, et al. 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem. 2022 Apr 14;65 (7) :5830-5849.