PUL89 Endonuclease-IN-1
PUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 value of 0.88 μM and has antiviral activitiy[1].
Product Specifications
CAS Number
[391680-92-5]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
CMV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pul89-endonuclease-in-1.html
Solubility
10 mM in DMSO
Smiles
COC(C1=C(C(O)=NC(C2=CC=CS2)=N1)O)=O
Molecular Formula
C10H8N2O4S
Molecular Weight
252.25
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Tianyu He, et al. 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem. 2022 Apr 14;65 (7) :5830-5849.|[2]ianyu He, et al. 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem. 2022 Apr 14;65 (7) :5830-5849.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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