LDC0496
Product Specifications
UNSPSC Description
LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ldc0496.html
Solubility
10 mM in DMSO
Smiles
CC(C=CC(C1=C(NC2=NC=C(C=C21)C(OC(C)C)=O)C3=CC=C(C=C3)N4CCN(CC4)C)=C5)=C5NC(C=C)=O
Molecular Weight
537.65
References & Citations
[1]Lategahn J, et al. Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J Med Chem. 2022;65(9):6643-6655.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146262/LDC0496-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146262/
Clinical Information
No Development Reported
CAS Number
2411874-83-2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
