HCAIX/XII-IN-4
HCAIX/XII-IN-4 (compound 6c) is a potent CAIX/XII inhibitor with the Ki values of 4.5 nM, 23.6 nM, >10000 nM and >10000 nM for CAXII, CAIX, CAI and CAII, respectively[1].
Product Specifications
CAS Number
1119200-33-7
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hcaix-xii-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C)C2=C(O1)C=C(OCC3=NOC(C4=CC=C(OC)C=C4)=N3)C=C2
Molecular Formula
C20H16N2O5
Molecular Weight
364.35
References & Citations
[1]Thacker PS, et, al. Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 May;98:103739.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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