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HCAIX/XII-IN-3

HCAIX/XII-IN-3 (compound 6q) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 66.2, 4.4 nM for hCAI, hCAII, hCAIX and hCAXII, respectively[1].

Product Specifications

CAS Number

2414629-94-8

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hcaix-xii-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C)C2=C(O1)C=C(OCC3=NOC(C4=CC=C(C(F)(F)F)C=C4)=N3)C=C2

Molecular Formula

C20H13F3N2O4

Molecular Weight

402.32

References & Citations

[1]Thacker PS, et al. Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 May;98:103739.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CA IX

Frequently Asked Questions

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