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HCAXII-IN-5

HCAXII-IN-5 (compound 6o) is a potent and selective hCAXII inhibitor with Ki values of >10000, >10000, 286.1, 1.0 nM for hCAI, hCAII, hCAIX and hCAXII, respectively[1].

Product Specifications

CAS Number

2414629-92-6

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hcaxii-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C)C2=C(O1)C=C(OCC3=NOC(C4=CC=C(C(C)(C)C)C=C4)=N3)C=C2

Molecular Formula

C23H22N2O4

Molecular Weight

390.43

References & Citations

[1]Thacker PS, et al. Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 May;98:103739.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CA II

Frequently Asked Questions

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