CDK1/2/4-IN-1

CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].

Product Specifications

CAS Number

[2414633-49-9]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; CDK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk1-2-4-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)SC(NC)=N1)/C=C/C2=CC=C(OC)C=C2

Molecular Formula

C15H16N2O2S

Molecular Weight

288.36

References & Citations

[1]Farghaly TA, et, al. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. Bioorg Chem. 2020 May;98:103761.