HCAXII-IN-4
HCAXII-IN-4 (compound 5j) is a potent and selective CA XII inhibitor with an Ki value of 6.4 nM for human CA XII[1].
Product Specifications
CAS Number
2414601-79-7
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaxii-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NNC(NCC1=CC=C(OC)C=C1)=O)C2CCN(C(C3=CC=C(S(=O)(N)=O)C=C3)=O)CC2
Molecular Formula
C22H27N5O6S
Molecular Weight
489.54
References & Citations
[1]Moi D, et al. Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors. Bioorg Chem. 2020 May;98:103728.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA XII
Frequently Asked Questions
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