BuChE-IN-6
BuChE-IN-6 (compound 1b) is a potent and selective BuChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.46 and 0.51 μM for eqBuChE and hBuChE, respectively. BuChE-IN-6 also inhibits Aβ42 self-aggregation[1].
Product Specifications
CAS Number
2003213-07-6
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/buche-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CC2=CN([C@@H]3[C@H](C(C)C)CC[C@@H](C)C3)N=N2)C4=C(C=CC=C4)C1=O
Molecular Formula
C21H26N4O2
Molecular Weight
366.46
References & Citations
[1]Marques CS, et al. N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study. Bioorg Chem. 2020 May;98:103753.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE
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