TFMU-ADPr (triethylamine)

TFMU-ADPr triethylamine is a general substrate for monitoring poly (ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr triethylamine can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr triethylamine has excellent reactivity, generality, stability, and usability. TFMU-ADPr triethylamine is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes[1].

Product Specifications

UNSPSC

12352005

Target

Poly (ADP-ribose) Glycohydrolase (PARG)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tfmu-adpr-triethylamine.html

Purity

97.26

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@@H]([C@@H]([C@@H]2O)O)OC3=CC=C(C(C(F)(F)F)=CC(O4)=O)C4=C3)(O)=O)(O)=O)([H])N5C6=NC=NC(N)=C6N=C5.CCN(CC)CC.[2.5]

Molecular Formula

C25H26F3N5O16P2.2.5C6H15N

Molecular Weight

1024.42

References & Citations

[1]Drown BS, et al. Monitoring Poly (ADP-ribosyl) glycohydrolase Activity with a Continuous Fluorescent Substrate. Cell Chem Biol. 2018 Dec 20;25 (12) :1562-1570.e19.