EGFR/HER2/TS-IN-2

EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 μM[1].

Product Specifications

CAS Number

[2444364-04-7]

UNSPSC

12352005

Target

EGFR; Thymidylate Synthase

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-her2-ts-in-2.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(N2N=C(C)C=C2C)N=C(SCC(NC3=NC4=C(S3)C=C(C)C=C4)=O)N=C1C5=CC=CC=C5

Molecular Formula

C26H21N7OS2

Molecular Weight

511.62

References & Citations

[1]Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976.