MMP-9-IN-5
MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM) . MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers[1].
Product Specifications
CAS Number
[2581824-80-6]
UNSPSC
12352005
Target
Akt; Apoptosis; MMP
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mmp-9-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N(C1=CC=CC=C1)C(C2=C(I)C=CC=C2)=O)C3=CC=CC=C3)NC4=CC=C(C=C4)[N+]([O-])=O
Molecular Formula
C27H20IN3O4
Molecular Weight
577.37
References & Citations
[1]Mohammed Salah Ayoup, et al. Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis. Eur J Med Chem. 2020 Jan 15;186:111875.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-1; MMP-13; MMP-2; MMP-9
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