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MMP-9-IN-3

MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM) . MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers[1].

Product Specifications

CAS Number

2581824-48-6

UNSPSC

12352005

Target

Akt; Apoptosis; MMP

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mmp-9-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(C(N(C(CC1=CC=CC=C1)=O)CC2=CC=CC=C2)C3=CC=CC=C3)NC4=CC=C(C=C4)[N+]([O-])=O

Molecular Formula

C29H25N3O4

Molecular Weight

479.53

References & Citations

[1]Mohammed Salah Ayoup, et al. Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis. Eur J Med Chem. 2020 Jan 15;186:111875.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MMP-1; MMP-13; MMP-2; MMP-9

Frequently Asked Questions

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