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CDK4/6-IN-13

As a cdk4/6 inhibitor. Compounds 10B and 10C showed low nanomolar activity, ideal antiproliferative activity, excellent metabolic properties and acceptable pharmacokinetics on cdk4/6.

Product Specifications

CAS Number

1908454-70-5

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk4-6-in-13.html

Solubility

10 mM in DMSO

Smiles

CC(C1=C(C2=CN=C(N=C2N3C=C(N=C13)C(C)C)NC4=CC=C(C=C4)N5CCNCC5)C)=O

Molecular Formula

C25H29N7O

Molecular Weight

443.54

References & Citations

[1]Shi C, et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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