Tubulin polymerization-IN-14
Tubulin polymerization-IN-14 (Compound 20a) is a tubulin polymerization inhibitor with an IC50 of 3.15 μM. Tubulin polymerization-IN-14 shows potent anti-vascular and anticancer activities, induces cancer cell apoptosis[1].
Product Specifications
CAS Number
2417134-05-3
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-14.html
Solubility
10 mM in DMSO
Smiles
C=C(C1=CC(Cl)=NC(NC)=C1)C2=CC=C(C(O)=C2)OC
Molecular Formula
C15H15ClN2O2
Molecular Weight
290.74
References & Citations
[1]Shuai W, et al. Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors. Eur J Med Chem. 2020 Jul 1;197:112308.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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