PDE4B/7A-IN-1

PDE4B/7A-IN-1 (compound 7) is a PDE4B/PDE7A inhibitor (PDE4B, IC50=80.4 μM) and 5-HT1A/5-HT-7R antagonist. PDE4B/7A-IN-1 has membrane-penetrating activity and high metabolic stability. PDE4B/7A-IN-1 exhibits antidepressant properties in rat behavioral tests[1].

Product Specifications

CAS Number

[2511632-25-8]

UNSPSC

12352005

Target

5-HT Receptor; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pde4b-7a-in-1.html

Solubility

10 mM in DMSO

Smiles

COC1=C(C=CC=C1)N2CCN(CC2)CCCC(NC3=CC(C(C)(C)C)=CC=C3O)=O

Molecular Formula

C25H35N3O3

Molecular Weight

425.56

References & Citations

[1]Jankowska A, et al. Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity. Eur J Med Chem. 2020 Sep 1;201:112437.