NHEJ inhibitor-1
NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt (II) complex, alleviates the non-homologous end connection (NHEJ) /homologous recombination (HR) -related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC) . NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin. NHEJ inhibitor-1 also induces ROS generation and MMP deduction[1].
Product Specifications
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nhej-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12CS[C@H]([C@]1(NC(N2)=O)[H])CCCCC(NCCN3C(C4=CC=CC5=C4C(C3=O)=CC=C5/N=C6CC7(C(O[Pt]([NH3])(OC7=O)[NH3])=O)C/6)=O)=O
Molecular Formula
C30H35N7O8PtS
Molecular Weight
848.79
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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