Topoisomerase II inhibitor 9
Selected Variant
HY-146189
Size: 1 Each
Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells[1].
Product Specifications
CAS Number
2413901-61-6
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-ii-inhibitor-9.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(S(=O)(NC2=NC=CC=C2)=O)C=C1)CSC3=NC4=C(N5C3=NN=C5)C=CC=C4
Molecular Formula
C22H17N7O3S2
Molecular Weight
491.55
References & Citations
[1]Eissa IH, et al. Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors. Arch Pharm (Weinheim) . 2019 Nov;352 (11) :e1900123.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Price
Sign In for Pricing
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400218-100 1x 100 µL
CD100 (Semaphorin-4D) (A8), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881124-500 1x 500 µL
TOX3 (TOX3/1124), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
PB9210-Biotin 100 µg/Vial
Anti-HCN1 Antibody Picoband® (Biotine Conjugate)
Sign In for Pricing
View Details 
PA1203-carrier-free 100 µg/Vial
Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody Picoband®, Carrier-free
Sign In for Pricing
View Details 
BNC550881-500 1x 500 µL
Androgen Receptor (AR441), CF555 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNCB0868-100 1x 100 µL
Golgi Complex (AE-6), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details