Topoisomerase II inhibitor 9

Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells[1].

Product Specifications

CAS Number

[2413901-61-6]

UNSPSC

12352005

Target

Apoptosis; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-ii-inhibitor-9.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(S(=O)(NC2=NC=CC=C2)=O)C=C1)CSC3=NC4=C(N5C3=NN=C5)C=CC=C4

Molecular Formula

C22H17N7O3S2

Molecular Weight

491.55

References & Citations

[1]Eissa IH, et al. Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors. Arch Pharm (Weinheim) . 2019 Nov;352 (11) :e1900123.