Topoisomerase II inhibitor 8
Selected Variant
HY-146188
Size: 1 Each
Topoisomerase II inhibitor 8 (compound 22) is a potent topoisomerase II inhibitor, with an IC50 of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase[1].
Product Specifications
CAS Number
2493298-68-1
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-ii-inhibitor-8.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CO1)SC2=NN=C3N2C4=C(C=CC=C4)NC3=O
Molecular Formula
C14H8N4O3S
Molecular Weight
312.30
References & Citations
[1]Abbass EM, et, al. Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers. Bioorg Chem. 2020 Nov;104:104255.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Price
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