Topoisomerase II inhibitor 8

Topoisomerase II inhibitor 8 (compound 22) is a potent topoisomerase II inhibitor, with an IC50 of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase[1].

Product Specifications

CAS Number

[2493298-68-1]

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-ii-inhibitor-8.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CO1)SC2=NN=C3N2C4=C(C=CC=C4)NC3=O

Molecular Formula

C14H8N4O3S

Molecular Weight

312.30

References & Citations

[1]Abbass EM, et, al. Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers. Bioorg Chem. 2020 Nov;104:104255.