CCT373567

CCT373567 is a potent molecular glue degrader of transcriptional repressor BCL6, with an IC50 of 2.9 nM. CCT373567 exhibits antiproliferative activity[1].

Product Specifications

CAS Number

[2378853-67-7]

UNSPSC

12352005

Target

Bcl-2 Family; Molecular Glues

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cct373567.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C)C2=C(C=C(NC3=NC(N4C[C@@H](O)C[C@@H](C)C4)=NC=C3Cl)C=C2)C5=C1OCC(F)(F)[C@H](C6CC6)N5

Molecular Formula

C26H29ClF2N6O3

Molecular Weight

547.00

References & Citations

[1]Huckvale R, et, al. Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo. J Med Chem. 2022 Jun 23;65 (12) :8191-8207.