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KCa1.1 channel activator-1

KCa1.1 channel activator-1 (compound 1E), a Quercetin hybrid derivative, is a selective vascular KCa1.1 channel channel stimulator. KCa1.1 channel activator-1 also displays CaV1.2 channel blocking activity. KCa1.1 channel activator-1 exhibits weak myorelaxant activity[1].

Product Specifications

UNSPSC

12352005

Target

Calcium Channel; Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kca1-1-channel-activator-1.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1=CC=C(C=C1O)C2=C(C(C3=C(O2)C=C(C=C3O)O)=O)O)/C=C/C4=CC=C5OCOC5=C4

Molecular Formula

C25H16O10

Molecular Weight

476.39

References & Citations

[1]Carullo G, et, al. Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular K Ca 1.1 channel stimulators. Bioorg Chem. 2020 Dec;105:104404.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

L-type calcium channel

Frequently Asked Questions

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