KCa1.1 channel activator-1
KCa1.1 channel activator-1 (compound 1E), a Quercetin hybrid derivative, is a selective vascular KCa1.1 channel channel stimulator. KCa1.1 channel activator-1 also displays CaV1.2 channel blocking activity. KCa1.1 channel activator-1 exhibits weak myorelaxant activity[1].
Product Specifications
UNSPSC
12352005
Target
Calcium Channel; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kca1-1-channel-activator-1.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1=CC=C(C=C1O)C2=C(C(C3=C(O2)C=C(C=C3O)O)=O)O)/C=C/C4=CC=C5OCOC5=C4
Molecular Formula
C25H16O10
Molecular Weight
476.39
References & Citations
[1]Carullo G, et, al. Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular K Ca 1.1 channel stimulators. Bioorg Chem. 2020 Dec;105:104404.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel
Frequently Asked Questions
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