Anticancer agent 69

Anticancer agent 69 (Compound 34), a potent and selective anticancer agent, potently and selectively inhibits human prostate cancer cell line PC3 (IC50=26 nM) . Anticancer agent 69 increases ROS level, down-regulates EGFR and induces apoptosis[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Apoptosis; EGFR; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-69.html

Solubility

10 mM in DMSO

Smiles

[H]/C(C1=CC=CC=N1)=N\NC2=NC(SCCC)=NC3=C2N=NN3CCCCCC

Molecular Formula

C19H26N8S

Molecular Weight

398.53

References & Citations

[1]Chenhao Xu, et al. Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazone fragment as potent and selective anticancer agents. Bioorg Chem. 2020 Dec;105:104424.