Metallo-β-lactamase-IN-8
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity[1].
Product Specifications
CAS Number
1610537-25-1
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/metallo-β-lactamase-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(NS(=O)(C2=CC=C(Cl)C=C2)=O)C=C1
Molecular Formula
C13H11ClN2O4S
Molecular Weight
326.76
References & Citations
[1]Li JQ, et, al. Hydroxamic acid with benzenesulfonamide: An effective scaffold for the development of broad-spectrum metallo-β-lactamase inhibitors. Bioorg Chem. 2020 Dec;105:104436.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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